Choosing the Right Mosquito Repellent

With dozens of repellent products on the market, picking the right one can be overwhelming. The key is understanding the active ingredient, its effectiveness, duration of protection, and safety profile. This guide breaks down the main options so you can make an informed choice.

The Main Repellent Ingredients

DEET (N,N-Diethyl-meta-toluamide)

DEET has been the gold standard in mosquito repellents since the 1940s and remains among the most well-studied repellent compounds available. Key facts:

  • Effective against mosquitoes, ticks, and many other biting insects
  • Available in concentrations from 5% to 100% — higher concentrations last longer, not necessarily work better
  • A 20–30% DEET product provides several hours of protection
  • Safe for adults and children over 2 months when used as directed
  • Can damage synthetic fabrics and some plastics

Picaridin (also known as Icaridin)

Picaridin is a newer synthetic repellent that rivals DEET in effectiveness and is often preferred for its feel on skin:

  • Odorless and non-greasy — more pleasant to use than DEET for many people
  • Does not damage fabrics or plastics
  • Effective against mosquitoes, ticks, and flies
  • A 20% concentration provides protection comparable to 20% DEET
  • Widely recommended by health authorities for travelers

IR3535

IR3535 is a biopesticide that has been used in Europe for decades. It is effective, has a good safety profile, and is less irritating to skin than DEET. It is particularly popular in products marketed for children.

Oil of Lemon Eucalyptus (OLE) and PMD

OLE is the only plant-based repellent recommended by the U.S. Centers for Disease Control and Prevention (CDC). It is derived from eucalyptus and provides reasonable protection — comparable to low-concentration DEET products — but is not recommended for children under 3 years. Note that OLE is different from pure lemon eucalyptus essential oil, which has not been proven effective.

Natural/Essential Oil Repellents

Products containing citronella, lavender, peppermint, or clove oil are widely marketed but generally provide only short-duration protection (often under 30 minutes). They may be suitable for low-risk, short-duration outdoor activities but are not recommended for areas with mosquito-borne disease risk.

Side-by-Side Comparison

IngredientEffectivenessDurationSkin FeelSafe for Kids?
DEET (20–30%)Excellent4–6 hoursSlightly oilyYes (2+ months)
Picaridin (20%)Excellent4–8 hoursLight, odorlessYes (2+ months)
IR3535Good2–4 hoursMildYes
OLE / PMDGood2–3 hoursVariesNo (under 3)
Essential oilsLimited<30 minutesPleasantCheck product

Application Tips for Maximum Protection

  1. Apply repellent to exposed skin only — not under clothing.
  2. If using sunscreen, apply sunscreen first, then repellent on top.
  3. Avoid applying to cuts, wounds, or irritated skin.
  4. Wash treated skin with soap and water when returning indoors.
  5. Do not apply repellent to young children's hands, eyes, or mouth.
  6. Reapply as directed — especially after swimming or sweating.

The Bottom Line

For most people, Picaridin offers the best balance of effectiveness, safety, and user comfort. DEET remains the most proven option for high-risk environments. Avoid relying solely on essential oil products when in areas with dengue, malaria, or other mosquito-borne disease risk.